반응 #66835

반응 방정식

tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate

tert-Butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate

5-amino-2,4-difluorophenol

→

title compound

2,4-Difluoro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

반응 조건

후처리

1. 1
   기타to yield 740 mg (16%)

실험 절차

The title compound was prepared in analogy to Example 65A from tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate from Example 11A (4.00 g, 12.3 mmol) and 5-amino-2,4-difluorophenol (1.87 g, 12.9 mmol) to yield 740 mg (16%).

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