반응 #66786

반응 방정식

1,2-dichloro-4-nitrobenzene

pyridin-2-ylmethanol

potassium hydroxide

water

→

title compound

수율 48.3%

2-[(2-Chloro-4-nitrophenoxy)methyl]pyridine

수율 48.3%

용매

toluene

반응 조건

후처리

1. 1
   기타The layers were separated
2. 2
   workup.ADDITIONthe organic layer was diluted with ethyl acetate
3. 3
   세척washed with water
4. 4
   건조The organic layer was dried over sodium sulfate
5. 5
   기타the solvent was removed in vacuo
6. 6
   기타The residue was triturated with petroleum ether and tert-butyl methyl ether

실험 절차

To a mixture of pyridin-2-ylmethanol (6.82 g, 62.5 mmol), Aliquat 336 (8.08 g, 20.0 mmol), potassium hydroxide (3.51 g, 62.5 mmol) and water (40 mL) were added toluene (80 mL) and 1,2-dichloro-4-nitrobenzene (10.0 g, 52.1 mmol). The mixture was heated to 60° C. overnight with vigorous stirring. The layers were separated, and the organic layer was diluted with ethyl acetate and washed with water. The organic layer was dried over sodium sulfate, and the solvent was removed in vacuo. The residue was triturated with petroleum ether and tert-butyl methyl ether to yield 6.66 g (48%) of the title compound.

출처