반응 #66753

반응 방정식

5-{1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinamide

HCl

→

compound

5-{4-Oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinamide dihydrochloride

용매

dioxane

dioxane

반응 조건

후처리

1. 1
   여과The resulted precipitate was filtered
2. 2
   세척washed with dioxane and Et2O

실험 절차

5-{1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinamide (1.30 g) was suspended in dioxane (10 ml) and 4N HCl in dioxane (20 ml) was added thereto, and stirred at room temperature for 18 h. The resulted precipitate was filtered, washed with dioxane and Et2O to obtain the intended compound as a colorless solid.

출처