반응 #667479

반응 방정식

2-Amino-2,3-dimethylbutyramide

furo[2,3-b]pyridine-5,6-dicarboxylic acid anhydride

→

6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]furo[2,3-b]pyridine-5-carboxylic acid

수율 97.9%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.STIRRINGThe reaction mixture is then stirred at 60° C. for one hour
2. 2
   온도cooled to room temperature
3. 3
   workup.ADDITIONadded
4. 4
   여과the solid filtered off
5. 5
   기타dried

실험 절차

2-Amino-2,3-dimethylbutyramide (2.1 g, 0.016 mol) is added to a stirred suspension of furo[2,3-b]pyridine-5,6-dicarboxylic acid anhydride (3.0 g, 0.016 mol) in tetrahydrofuran (7.5 mL) and the mixture allowed to stir at room temperature for 16 hours. The reaction mixture is then stirred at 60° C. for one hour, cooled to room temperature, either added, and the solid filtered off and dried to give 5 g of 6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]furo[2,3-b]pyridine-5-carboxylic acid mp 192°-196° C. (dec).

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