반응 #6673

반응 방정식

phenothiazine

iodoethane

potassium hydroxide

→

10-Ethylphenothiazine

용매

toluene

반응 조건

후처리

1. 1
   온도was refluxed for 24 hours
2. 2
   온도After cooling
3. 3
   여과the reaction mixture was filtered
4. 4
   기타the solvent was evaporated
5. 5
   기타The product was crystallized from methanol

실험 절차

A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.

출처