반응 #66729

반응 방정식

4-Oxo-adamantane-1-carboxylic acid methyl ester

→

( 11 )

수율 91.5%

4-Oxo-adamantane-1-carboxylic acid

수율 91.5%

용매

LiOH MeOH

MeOH LiOH

반응 조건

후처리

1. 1
   workup.STIRRINGstirring
2. 2
   추출extracted three times with ethyl acetate
3. 3
   건조The organic layer was dried over sodium sulphate
4. 4
   기타evaporated to dryness

실험 절차

1.64 g of 4-Oxo-adamantane-1-carboxylic acid methyl ester (10) were dissolved in 4 mL of 2M aq. LiOH/MeOH (1:1) and stirred overnight at room temperature. Additional 5 ml of the MeOH/LiOH mixture were added and stirring was continued until conversion was complete. The reaction mixture was acidified and extracted three times with ethyl acetate. The organic layer was dried over sodium sulphate and evaporated to dryness to give 1.4 g of (11) as a solid. Rt=0.87 min (Method 3). Detected mass: 195.2 (M+H+).

출처