반응 #66726

반응 방정식

4-allyl-4-amino-adamantan-1-ol

4-Allyl-4-amino-adamantan-1-ol

→

title compound

수율 76.9%

4-Propyl-4-amino-adamantan-1-ol

수율 76.9%

용매

methanol

반응 조건

후처리

1. 1
   기타The catalyst was removed by filtration
2. 2
   기타the filtrate was evaporated in vacuo

실험 절차

A solution of 4-allyl-4-amino-adamantan-1-ol (3, 3.6 g, 17.4 mmol) in methanol (50 mL) was treated with 50 mg of 10% palladium on activated carbon and the mixture was stirred overnight under a hydrogen atmosphere (1 atm) at room temperature. The catalyst was removed by filtration, and the filtrate was evaporated in vacuo to give 2.8 g of the title compound as diastereomeric mixture (4). Rt=0.21 min, 0.73 min (Method 3). Detected mass: 210.2 (M+H+).

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