반응 #66722

반응 방정식

racemic ethyl 4-amino-3-methoxypiperidine-1-carboxylate

benzyl bromide

potassium carbonate

potassium iodide

→

ethyl 4-(dibenzylamino)-3-methoxypiperidine-1-carboxylate

용매

water

DMF

반응 조건

후처리

1. 1
   추출extracted with, for example, ethyl acetate
2. 2
   세척The organic layer was washed with brine
3. 3
   기타dried over anhyh
4. 4
   여과Subsequent filtration and concentration of the solvent
5. 5
   기타provided the 1 as the yellow-orange oil (1 part by mole)

실험 절차

To a solution of racemic ethyl 4-amino-3-methoxypiperidine-1-carboxylate (1 part by mole) in DMF were added benzyl bromide (about 2.2 part by mole), potassium carbonate (about 2.4 part by mole) and potassium iodide (about 0.2 part by mole) respectively. The reaction was heated to about 80° C. After about 6 hours, the reaction was slowly diluted with water (about 12 parts by volume) and extracted with, for example, ethyl acetate. The organic layer was washed with brine and then dried over anhyh. Na2SO4. Subsequent filtration and concentration of the solvent provided the 1 as the yellow-orange oil (1 part by mole).

출처