반응 #66672

반응 방정식

2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene

ICl

NaHCO3

→

1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene

수율 91.8%

용매

HOAc

HOAc

H2O

반응 조건

후처리

1. 1
   추출The aqueous solution was extracted into EtOAc which
2. 2
   세척was washed with water, brine
3. 3
   건조dried over Na2SO4
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo

실험 절차

To a solution of 2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene (10 g, 31.25 mmol) in HOAc (10 ml) was added a solution of ICl (9.6 g, 59.26 mmol) in HOAc (10 ml) and H2O (5 ml). The reaction mixture was stirred at room temperature for 16 hrs and basified by saturated NaHCO3 solution. The aqueous solution was extracted into EtOAc which was washed with water, brine, dried over Na2SO4, filtered and concentrated in vacuo to give 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene (12.35 g, 89%).

출처