반응 #66556

반응 방정식

Toluene

product

(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-ethyl-1-piperazinecarboxylic Acid, 1,1-Dimethylethyl Ester

trifluoroacetic acid

→

sub-titled compound

[4-Chloro-2-[[(3S)-3-ethyl-1-piperazinyl]methyl]phenoxy]-acetic Acid, 1,1-dimethylethyl Ester Trifluoroacetate Salt

용매

dichloromethane

반응 조건

후처리

1. 1
   기타reaction
2. 2
   농축was concentrated (bath temp <40° C.) in vacuo

실험 절차

To a solution of the product from example 69 part e) (2 g) in dichloromethane (100 ml) was added trifluoroacetic acid (100 ml). The mixture was stirred at RT for 24 h. Toluene (100 ml) was added and reaction was concentrated (bath temp <40° C.) in vacuo to give the sub-titled compound as a yellow oil (3.10 g).

출처