반응 #6655
ord-8a817766383541e695f1bd93a0b40edf
반응 방정식
6-chloronicotinic acid
ethanol
dicyclohexylcarbodiimide
dimethylaminopyridine
→
title compound
Ethyl 6-chloronicotinate
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도was heated
- 2온도at reflux for 2 hours
- 3온도to cool
- 4기타solvent removed in vacuo
실험 절차
A mixture of 15.75 g (0.1 mol) 6-chloronicotinic acid, 6.9 g (0.15 mol) ethanol, 22.7 g (0.11 mol) dicyclohexylcarbodiimide and 3.7 g dimethylaminopyridine in 200 ml methylene chloride was heated at reflux for 2 hours. The mixture was allowed to cool, solvent removed in vacuo and the residue subjected to flash chromatography to give the title compound as a low-melting white solid. PMR (CDCl3): δ 1.44 (3H, t, J~6.2 Hz) 4.44 (2H, q, J~4.4 Hz), 7.44 (1H, d, J~8.1 Hz), 8.27 (1H, dd, J~8.1 Hz, 3 Hz), 9.02 (1H, d, J~3 Hz).