반응 #66516

반응 방정식

thiophene-2-carbonyl chloride

3-methoxyaniline

DIEA

→

N-(3-methoxyphenyl)thiophene-2-carboxamide

수율 70.1%

용매

DCM

DCM

반응 조건

후처리

1. 1
   세척The organic phase was washed with HCl 1 M solution
2. 2
   건조with a saturated solution of NaHCO3, was dried over MgSO4
3. 3
   여과was filtered
4. 4
   농축was concentrated under reduced pressure

실험 절차

According to Scheme 1 Method A: A solution of thiophene-2-carbonyl chloride (2.92 mmol, 0.31 mL) in DCM (1 mL) was added to solution of 3-methoxyaniline (2.44 mmol, 0.27 mL) and DIEA (4.87 mmol, 0.87 mL) in DCM (4 mL) at 0° C. The reaction mixture was stirred at room temperature for 1 hour. The organic phase was washed with HCl 1 M solution, then with a saturated solution of NaHCO3, was dried over MgSO4, was filtered and was concentrated under reduced pressure to yield N-(3-methoxyphenyl)thiophene-2-carboxamide (1.71 mmol, 0.40 g, 70%) as a white solid.

출처