반응 #66503

반응 방정식

3-ethynyl aniline

methanesulfonyl chloride

→

methanesulfonamide

N-(3-ethynylphenyl)methanesulfonamide

용매

pyridine

반응 조건

후처리

1. 1
   기타was then evaporated
2. 2
   workup.ADDITIONThe residue was treated with 2 N aq. HCl (25 mL)
3. 3
   추출subsequently extracted with ethyl acetate (2×30 mL)
4. 4
   건조The combined organic layers were dried over MgSO4
5. 5
   기타evaporated

실험 절차

To a solution of 3-ethynyl aniline (1.05 mL, 10.0 mmol) in pyridine (5 mL) was added methanesulfonyl chloride (857 μL, 1.10 eq.) at a temperature of 0° C. The resulting mixture was stirred overnight at room temperature and was then evaporated. The residue was treated with 2 N aq. HCl (25 mL) and subsequently extracted with ethyl acetate (2×30 mL). The combined organic layers were dried over MgSO4 and evaporated to give the desired methanesulfonamide in quantitative yield. It was used without further purification.

출처