반응 #66494

반응 방정식

3-amino-1-propanol

N-ethyldiisopropylamine

2,4-dichloro-5-iodo-pyrimidine

→

3-(2-chloro-5-iodopyrimidine-4-ylamino)propan-1-ol

수율 95.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타provided the target compound after column chromatography in 95% yield

실험 절차

In analogy to GP 2 reaction of 3-amino-1-propanol (0.38 ml, 5 mmol) in the presence of N-ethyldiisopropylamine (1.74 ml, 10 mmol) in 150 ml acetonitrile with 2,4-dichloro-5-iodo-pyrimidine (1.51, 5.5 mmol) provided the target compound after column chromatography in 95% yield.

출처