반응 #66420

반응 방정식

(4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide

phthalic anhydride

→

desired compound

수율 55.0%

[4-(1,3-dioxobenzo[c]azolidin-2-yl)phenyl]-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide

수율 55.0%

용매

DMF

반응 조건

후처리

1. 1
   온도the mixture was cooled
2. 2
   기타purified by RP-HPLC

실험 절차

A 22 mg portion (0.070) of (4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide was combined with 15 mg (0.10 mmol) of phthalic anhydride in 140 μL of DMF. After 18 h of heating at 110° C., the mixture was cooled and purified by RP-HPLC, to give 20 mg (55%) of the desired compound. ES-MS (M+H)+=447 (Cl).

출처