반응 #663543

반응 방정식

benzoate

2-Chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)benzyl benzoate

→

title compound 105

수율 100.5%

(2-Chloro-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methanol

수율 100.5%

용매

THF MeOH H2O

반응 조건

후처리

1. 1
   추출The mixture was extracted with EtOAc/aq
2. 2
   건조The organic layer was dried over anhydrous MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated in vacuo

실험 절차

To a solution of benzoate 104 (6.13 g, 7.97 mmol) in THF/MeOH/H2O (150 mL/5 mL/5 mL) was added LiOH monohydrate (1.0 g, 23.9 mmol) at room temperature. The mixture was stirred at room temperature for 15 hours. The mixture was extracted with EtOAc/aq. saturated NH4Cl solution (100 mL/100 mL). The organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo to yield the title compound 105 (5.33 g, 10%), which was carried on to the next step without further purification.

출처