반응 #66324

반응 방정식

2,4-Dichloropyrimidine-5-carbonyl chloride

2,2,2-trifluoroethylamine

triethylamine

→

solid

수율 60.0%

2,4-dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

수율 60.0%

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타The reaction mixture was purified by flash chromatography

실험 절차

2,4-Dichloropyrimidine-5-carbonyl chloride (1 g, 5 mmol) was dissolved in CH2Cl2 (20 mL), 2,2,2-trifluoroethylamine (515 mg, 5 mmol) and triethylamine (1.31 mL, 9 mmol) were added. The reaction mixture was stirred at 25° C. for 2 h. The reaction mixture was purified by flash chromatography to yield a white solid (780 mg, 60%). MS: m/z=271.9 [M−H]−.

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