반응 #663167

반응 방정식

Tert-butyl-3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidin-1-carboxylate

trifluoroacetic acid

→

title compound

수율 88.0%

3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidine

수율 88.0%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타Preparation
2. 2
   기타according to Preparation 15
3. 3
   기타Purification
4. 4
   세척on a Biotage Isolute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine, 4:1)

실험 절차

Preparation according to Preparation 15. Tert-butyl-3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidin-1-carboxylate (1.81 g, 5.5 mmol), methylene chloride (20 mL) and trifluoroacetic acid (5 mL). Purification on a Biotage Isolute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine, 4:1) gave the title compound (1.11 g, 88%). MS m/z (rel. intensity, 70 eV) 214 (38), 199 (73), 187 (bp), 157 (40), 133 (39).

출처