반응 #6611

반응 방정식

water

2-bromomethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

ethyl 4-hydroxybenzoate

potassium carbonate

→

title compound

수율 50.8%

4-Carbethoxyphenyl 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylmethyl ether

수율 50.8%

용매

dimethylformamide

반응 조건

후처리

1. 1
   추출extracted several times with ether
2. 2
   세척the organic phase was washed with water
3. 3
   건조dried over Na2SO4
4. 4
   농축concentrated
5. 5
   기타Recrystallization from methanol

실험 절차

10 g (36 mmol) of 2-bromomethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene, 6 g (36 mmol) of ethyl 4-hydroxybenzoate and 7.2 g (52 mmol) of anhydrous potassium carbonate in 60 ml of dimethylformamide were refluxed for 5.25 h. The mixture was then poured into water and extracted several times with ether, and the organic phase was washed with water, dried over Na2SO4 and concentrated. Recrystallization from methanol resulted in 6.7 g of the title compound of melting point 109°-11° C.

출처