반응 #66106

반응 방정식

Oxalyl chloride

2-phenyl-5,6,7,8-tetrahydro-indolizine

→

oxo-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetyl chloride

수율 91.2%

용매

toluene

THF

반응 조건

후처리

1. 1
   농축then concentrated under vacuum
2. 2
   기타The residue was triturated with petrol (5×300 mL)

실험 절차

Oxalyl chloride (17.2 mL, 0.19 mol) was added to an ice-cold solution of 2-phenyl-5,6,7,8-tetrahydro-indolizine (32 g, 0.16 mol) in a mixture of toluene (20 mL) and THF (30 mL). The reaction mixture was allowed to warm to room temperature and stirred for 30 min. then concentrated under vacuum. The residue was triturated with petrol (5×300 mL) to afford oxo-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetyl chloride (42 g, 89%) as a dark yellow solid.

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