반응 #66100

반응 방정식

2-Bromo-1-(1-bromo-cyclopentyl)-ethanone

α-picoline

→

1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt

수율 117.6%

용매

acetone

반응 조건

후처리

1. 1
   온도at reflux overnight
2. 2
   온도to cool
3. 3
   농축then concentrated in vacuo
4. 4
   세척The crude mass was washed with 30% ethyl acetate/petroleum ether and diethyl ether

실험 절차

2-Bromo-1-(1-bromo-cyclopentyl)-ethanone (3.7 g, 13.7 mmol) and α-picoline (1.02 g, 11.0 mmol) in acetone were heated at reflux overnight. The reaction mixture was allowed to cool then concentrated in vacuo. The crude mass was washed with 30% ethyl acetate/petroleum ether and diethyl ether. 1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt (3.65 g, 94%) was obtained as a semi-solid material and taken for next step without purification.

출처