반응 #66023

ord-abdd2696e4ea4b9884b1a01c9ed2ecdb

반응 방정식

CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonyl methyl-amino}-acetic acid tert-butyl ester
CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonylmethyl-amino}-aceticacid tert-butyl ester
→
O=C(O)CN(CC(=O)O)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-carboxymethyl-amino}-acetic acid

반응물

CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonyl methyl-amino}-acetic acid tert-butyl ester
CC(C)(C)OC(=O)CN(CC(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1
{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonylmethyl-amino}-aceticacid tert-butyl ester

시약

없음

용매

O=CO
formic acid

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonyl methyl-amino}-acetic acid tert-butyl ester (4b) (1.00 g, 2.03 mmol) was dissolved in formic acid (10 mL) and stirred overnight at room temperature.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08524194B2uspto-grants-2013_09