반응 #660089

반응 방정식

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

용매

piperidine

dimethylformamide

반응 조건

후처리

1. 1
   농축The reaction mixture can be concentrated under vacuum, water
2. 2
   workup.ADDITIONcan be added to the residue
3. 3
   추출the product can be extracted with ethyl acetate
4. 4
   기타The crude product can be purified by conversion into its hydrochloride salt

실험 절차

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) can be dissolved in 20% piperidine in dimethylformamide at 0° C. The solution can be stirred continuously for 1 h. The reaction mixture can be concentrated under vacuum, water can be added to the residue, and the product can be extracted with ethyl acetate. The crude product can be purified by conversion into its hydrochloride salt.

출처