반응 #659893

반응 방정식

2,2,4,4-tetramethyl-1,3-cyclobutanedione

TMPD glycol

potassium carbonate

→

product

수율 96.0%

3-Hydroxy-2,2,4-trimethylpentyl 2,2,4-trimethyl-3-oxopentanoate

수율 96.0%

용매

toluene

반응 조건

후처리

1. 1
   기타Reaction
2. 2
   온도was cooled
3. 3
   세척Organic layer was washed 4 times at 70° C
4. 4
   기타Toluene removed

실험 절차

To a 1-liter round bottom flask was charged 2,2,4,4-tetramethyl-1,3-cyclobutanedione (140.2 g, 1.0 moles), TMPD glycol (146.2 g, 1.0 moles) and potassium carbonate (73 g, 0.53 moles). The mixture was heated to 120° C. and held for 4 hours. Reaction was cooled and 200 mL of toluene added. Organic layer was washed 4 times at 70° C. Toluene removed to provide 275 g of product. GC assay of the product was 95.9% (4.6:1 mixture of two major isomers).

출처