반응 #65971

반응 방정식

hydroxy-indanone

cyanoacetic acid

→

hydroxyindene-3-acetic acid

반응 조건

후처리

1. 1
   기타In an alternative preparation scheme

실험 절차

In an alternative preparation scheme, the intermediate hydroxy-indanone can be reacted with cyanoacetic acid to give the corresponding hydroxyindene-3-acetic acid, which is then esterified before introduction of the R5 -methylene grouping in order to facilitate the purification of desired intermediates. Since introduction of the R5 -methylene grouping is accompanied by ester hydrolysis, the intermediate free acid is re-esterified to facilitate purification followed by reaction with an appropriate halo-alkyl-A group to yield the desired final product ##STR15## can be prepared by reacting a halo-indene-3-acetic acid with a A(CH2)n -containing benzaldehyde prepared from the corresponding individual components ##STR16##

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