반응 #659339

반응 방정식

2-[4-(imidazo[1,2-a]pyridin-8-yl)phenoxy]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole

hydrogen chloride-ethyl acetate

→

title compound

수율 76.6%

2-[4-(Imidazo[1,2-a]pyridin-8-yl)phenoxy]-1H-benzimidazole

수율 76.6%

용매

methanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도under reflux for 3 hr
3. 3
   농축The reaction mixture was concentrated under reduced pressure, saturated aqueous sodium hydrogen carbonate solution
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   추출the mixture was extracted with ethyl acetate
6. 6
   건조The extract was dried over anhydrous sodium sulfate
7. 7
   기타the solvent was evaporated under reduced pressure
8. 8
   기타The residue was recrystallized from ethyl acetate

실험 절차

A mixture of 2-[4-(imidazo[1,2-a]pyridin-8-yl)phenoxy]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole (0.53 g), 4 M hydrogen chloride-ethyl acetate solution (20 ml) and methanol (4 ml) was heated under reflux for 3 hr. The reaction mixture was concentrated under reduced pressure, saturated aqueous sodium hydrogen carbonate solution was added to the residue, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was recrystallized from ethyl acetate to give the title compound (0.29 g).

출처