반응 #65932

반응 방정식

3-Dipropylamino-5-aminochroman

2,5-dimethoxytetrahydrofuran

NaOH

→

title compound

3-Dipropylamino-5-(pyrrol-1-yl)chroman

용매

acetic acid

반응 조건

후처리

1. 1
   온도The solution was refluxed for 1 hour
2. 2
   추출extracted with toluene
3. 3
   건조The organic phase was dried with sodium sulfate
4. 4
   기타evaporated to dryness
5. 5
   기타The residue was purified by flash chromatography on silica gel by elution with ethyl acetate/hexane 1:9

실험 절차

3-Dipropylamino-5-aminochroman (Example 14; 0.60 g, 2.42 mmol) was dissolved in acetic acid (10 ml) and 2,5-dimethoxytetrahydrofuran (0.40 g, 3.0 mmol) was added. The solution was refluxed for 1 hour. The solution was neutralized with NaOH (aq.) and extracted with toluene. The organic phase was dried with sodium sulfate and evaporated to dryness. The residue was purified by flash chromatography on silica gel by elution with ethyl acetate/hexane 1:9 to give the title compound. 13C-NMR: 111.75 21.89 24.81 52.69 53.15 67.94 108.93 115.67 118.22 118.44 121.87 127.22 141.47 155.27.

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