반응 #6593

반응 방정식

4-(dimethylamino)benzyl alcohol

3-hydroxybenzaldehyde

triphenylphosphine

→

3-(4-(dimethylamino)-benzyloxy) benzaldehyde

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축Concentrate the solution in vacuo
2. 2
   workup.ADDITIONdilute with a small quantity of ethyl ether
3. 3
   여과Filter any precipitate
4. 4
   농축concentrate the filtrat in vacuo
5. 5
   기타Purify by silica gel chromatography

실험 절차

Mix 4-(dimethylamino)benzyl alcohol (3.35 g. 22 mmol), 3-hydroxybenzaldehyde (2.69 g, 22 mmol), triphenylphosphine (5.8 g, 22 mmol) and diethylazadicarboxylate (3.83 g, 22 mmol) in tetrahydrofuran (25 mL). Stir at room temperature under anhydrous atmosphere until the reaction is done. Concentrate the solution in vacuo and dilute with a small quantity of ethyl ether. Filter any precipitate and concentrate the filtrat in vacuo. Purify by silica gel chromatography to give 3-(4-(dimethylamino)-benzyloxy) benzaldehyde.

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