반응 #65919

반응 방정식

Cycloheptylamine

2-fluoreneacetic acid

1-hydroxybenztriazole

dicyclohexylcarbodiimide

→

N-cycloheptyl-2-fluoreneacetamide

수율 65.8%

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도ice-cooling
2. 2
   온도cooling
3. 3
   여과The resulting solid was filtered off
4. 4
   workup.DISTILLATIONthe filtrate was distilled under reduced pressure
5. 5
   추출The residue was extracted with 50 ml of chloroform
6. 6
   세척the extract was washed with 1N aqueous sodium hydroxide solution, 1N hydrochloric acid and water in the order
7. 7
   건조dried over anhydrous magnesium sulfate
8. 8
   workup.DISTILLATIONThe solvent was then distilled off under reduced pressure
9. 9
   기타the residue was purified by silica gel column chromatography

실험 절차

In dimethylformamide (50 ml) was dissolved 2-fluoreneacetic acid (2.24 g) followed by addition of 1-hydroxybenztriazole (2.0 g) and, then, dicyclohexylcarbodiimide (3.1 g) with constant stirring and ice-cooling. The mixture was further ,stirred at room temperature for 15 minutes. Cycloheptylamine (1.7 g) was then added under ice-cooling and the mixture was stirred at room temperature for 8 hrs. The resulting solid was filtered off and the filtrate was distilled under reduced pressure. The residue was extracted with 50 ml of chloroform and the extract was washed with 1N aqueous sodium hydroxide solution, 1N hydrochloric acid and water in the order mentioned and dried over anhydrous magnesium sulfate. The solvent was then distilled off under reduced pressure and the residue was purified by silica gel column chromatography to give 2.1 g of N-cycloheptyl-2-fluoreneacetamide as a solid.

출처