반응 #65887

반응 방정식

product

Methyl 6-phenyl-4-[(trimethylsilyl)-oxy]-hexa-3,5-dienoate

N-bromo-succinimide

→

expected product

수율 44.2%

Methyl 3-bromo-4-oxo-6-phenyl-5-hexenoate

수율 44.2%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The residue was chromatographed on silica
2. 2
   세척eluting with a hexane

실험 절차

A mixture of 4.2 g of the product of Step C, 40 ml of tetrahydrofuran and 2.7 g of N-bromo-succinimide was cooled to 0° C. and stirred for one hour at this temperature, then brought to dryness. The residue was chromatographed on silica, eluting with a hexane--ethyl acetate mixture (8-2) to obtain 1.9 g of the expected product. Thin layer chromatography; Rf=0.28 [eluant: hexane-- ethyl acetate (8-2)].

출처