반응 #65844

반응 방정식

sodium hydroxide

pyrocatechol

2-chloro-1,1,1,4,4,4-hexafluorobut-2-ene

→

2-(2,2,2-Trifluoroethyl)-2-trifluoromethyl-1,3-benzodioxole

용매

dimethylformamide

반응 조건

후처리

1. 1
   추출extracted with diethyl ether
2. 2
   세척The organic phase was washed with water
3. 3
   건조dried over magnesium sulphate
4. 4
   농축concentrated
5. 5
   workup.DISTILLATIONThe product was finally distilled under high vacuum

실험 절차

11 g of pyrocatechol were dissolved in 200 ml of dimethylformamide, and 18 g of 45% by weight aqueous sodium hydroxide solution were added. 20 g of 2-chloro-1,1,1,4,4,4-hexafluorobut-2-ene were added dropwise to the mixture at 75° C. The reaction mixture was subsequently stirred for 30 minutes at 75° C. and then poured into 500 ml of ice-water and extracted with diethyl ether. The organic phase was washed with water, dried over magnesium sulphate and concentrated. The product was finally distilled under high vacuum. The yield was 15 g (=56%) and the boiling point was 60° C. at 10 mbar. The NMR spectra showed the following characteristic absorptions: 19F NMR: -59.0 and -84.6 ppm. 1H NMR: 3.02 ppm.

출처