반응 #65806

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benzene

1-(2-bromocyclopenten-1-yl)-4-(methylthio)benzene

4-cyanophenylboronic acid

→

1-[2-(4-cyanophenyl)cyclopenten-1-yl]-4-(methylthio)benzene

수율 89.0%

반응 조건

후처리

1. 1
   기타Step 1 Purification by silica gel chromatography (MPLC) with hexane ethyl acetate (19:1)

실험 절차

Following the synthetic procedure outlined in Step 3 of Example 1, 500 mg (1.9 mmol) of 1-bromocyclopenten-1-yl)-4-methylthio) benzene (Example 1, Step 2) was reacted with 540 mg 3.7 mmol) of 4-cyanophenylboronic acid (Step 1 Purification by silica gel chromatography (MPLC) with hexane ethyl acetate (19:1) gave 480 mg (89%) of 1-[2-(4-cyanophenyl)cyclopenten-1-yl]-4-(methylthio)benzene as an oil: NMR (CDCl3) d 2.07 (m, J=7 Hz, 2H), 2.42 (s, 3H), 2.89 (t, J=7 Hz, 4H), 7.05 (d, J=8 Hz, 2H), 7.11 (d, J=8 Hz, 2H), 7.26 (d, J=8 Hz, 2H), 7.48 (d, J=8 Hz, 2H).

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