반응 #65805

반응 방정식

1-bromo-2-phenylcyclopentene

4-methylthiophenylboronic acid

→

1-(2-phenylcyclopenten-1-yl)-4-(methylthio)benzene

수율 89.0%

반응 조건

후처리

1. 1
   기타Purification by silica gel chromatography (MPLC) with hexane

실험 절차

Following a synthetic procedure which was similar to the one outlined in Step 3 of Example 1, 750 mg (3.4 mmol) of 1-bromo-2-phenylcyclopentene (Step 1) was reacted with 1.2 g (6.8 mmol) of 4-methylthiophenylboronic acid (Example 1, Step 1). Purification by silica gel chromatography (MPLC) with hexane gave 800 mg (89%) of 1-(2-phenylcyclopenten-1-yl)-4-(methylthio)benzene as an oil: NMR (CDCl3) d 2.00-2.17 (m, 2H), 2.46 (s, 3H), 2.86-3.01 (m, 4H), 7.08-7.19 (m, 4H), 7.19-7.32 (m, 5H).

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