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1-(2-bromocyclopenten-1-yl)-4-(methylthio) benzene

1-(2-bromocyclopenten-1-yl)-4-(methylthio)benzene

4-chlorophenylboronic acid

→

1-[2-(4-chlorophenyl)cyclopenten-1-yl]-4-(methylthio)benzene

수율 103.7%

반응 조건

후처리

1. 1
   기타Purification by silica gel chromatography (MPLC) with hexane

실험 절차

Following the synthetic procedure outlined in Step 3 of Example 1, 250 mg (0.93 mmol) of 1-(2-bromocyclopenten-1-yl)-4-(methylthio) benzene (Example 1, Step 2) was reacted with 300 mg (1.9 mmol) of 4-chlorophenylboronic acid (Lancaster). Purification by silica gel chromatography (MPLC) with hexane gave 290 mg of 1-[2-(4-chlorophenyl)cyclopenten-1-yl]-4-(methylthio)benzene as a colorless solid: mp 72°-74° C.; NMR (CDCl3) d 2.04 (m, J=7 Hz, 2H), 2.46 (s, 3H), 2.86 (n, J=7 Hz, 4H), 7.07-7.21 (m, 8H).

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