반응 #65756

반응 방정식

3-amino-6-chloro-4,5-diethoxycarbonyl-2-methylpyridine

hydrazine monohydrate

→

8-Amino-7-methylpyrido[3.4-d]pyridazine-1,4(2H,3H)dione

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe solvent is distilled off
2. 2
   여과the resultant crystals were collected by filtration with ethanol
3. 3
   workup.ADDITIONAfter water was added to the crystals

실험 절차

To 57 mg of 3-amino-6-chloro-4,5-diethoxycarbonyl-2-methylpyridine was added 0.5 ml of hydrazine monohydrate, and the mixture was heated in a stream of nitrogen at 100° C. for 30 minutes. The solvent is distilled off, and the resultant crystals were collected by filtration with ethanol. After water was added to the crystals, the mixture was neutralized with 1N hydrochloric acid.

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