반응 #65751

반응 방정식

3,4-diethoxycarbonyl-2-dimethylamino-5-nitro-6-phenylpyridine

→

3-Amino-4,5-diethoxycarbonyl-6-dimethylamino-2-phenylpyridine

용매

ethyl acetate

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타Catalytic reduction reaction
3. 3
   기타After the catalyst was removed
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   기타the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 1:2)

실험 절차

In 2 ml of ethyl acetate Was dissolved 52 mg of 3,4-diethoxycarbonyl-2-dimethylamino-5-nitro-6-phenylpyridine, whereto 50 mg of 10% Pd-C (50% wet) was added. Catalytic reduction reaction was conducted for 5.5 hours. After the catalyst was removed, the solvent was distilled off and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 1:2).

출처