반응 #657307

반응 방정식

methyl 3-(4-fluorophenyl)-3-oxopropanoate

hydrazine hydrate

diethyl ether

→

3-(4-fluorophenyl)-1H-pyrazol-5-ol

용매

acetic acid

반응 조건

후처리

1. 1
   온도is heated 3 h
2. 2
   온도under reflux
3. 3
   온도The resulting suspension is cooled down
4. 4
   여과The precipitate is filtered off
5. 5
   건조dried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol
6. 6
   기타are obtained as white solid

실험 절차

A mixture of methyl 3-(4-fluorophenyl)-3-oxopropanoate (10.0 g, 0.051 mol) and hydrazine hydrate (1.1 eq, 2.8 g, 0.056 mol) in 20 mL glacial acetic acid is heated 3 h under reflux. The resulting suspension is cooled down and 10 mL diethyl ether is added. The precipitate is filtered off, dried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol are obtained as white solid.

출처