반응 #65729

반응 방정식

(±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridone

2,3,4,6-tetra-O-acetylglucopyranosyl bromide

aluminum

→

(±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

용매

dichloromethane

반응 조건

후처리

1. 1
   여과Solid material was filtered off
2. 2
   농축the filtrate was concentrated under reduced pressure

실험 절차

(±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridone (1)(2.0 g) and 2,3,4,6-tetra-O-acetylglucopyranosyl bromide (4a)(5.6 g) were dissolved in dichloromethane (40 ml). To this solution, silver carbonate (1.8 g) was added. The mixture was stirred at room temperature for 24 hours while the vessel was shielded from light by an aluminum sheet. Solid material was filtered off, and the filtrate was concentrated under reduced pressure. As a result, (±)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (5a) was obtained. The compound (5a) obtained as above was subjected to the experiment of the following example without purification.

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