반응 #657273

반응 방정식

2-Amino propanoic acid

p-toluenesulphonic acid

Benzyl alcohol

water

→

2-amino propanoic acid benzyl ester

용매

toluene

dichloromethane

반응 조건

후처리

1. 1
   온도The reaction mixture was heated
2. 2
   온도under reflux for 2 h
3. 3
   기타The product was purified by flash chromatography

실험 절차

4.45 g (50 mMol) 2-Amino propanoic acid were added to 9.7 (51 mMol) p-toluenesulphonic acid and 20 ml (193 mMol) Benzyl alcohol in 10 ml toluene. The reaction mixture was heated under reflux for 2 h using a water separator. 30 ml dichloromethane was added to the cooled reaction mixture. The product was purified by flash chromatography using CH2Cl2:CH3OH 50:1.

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