반응 #657260

반응 방정식

trimethyl-3,4,5-pyrazoletricarboxylate

pyrazole

sodium hydride

trityl chloride

→

title compound

수율 90.0%

Trimethyl 1-trityl-3,4,5-pyrazoletricarboxylate

수율 90.0%

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타The synthesis of this compound
2. 2
   기타After removal of the solvent under vacuum
3. 3
   세척the resulting residue was washed with distilled water, n-hexane
4. 4
   기타finally dried under vacuum

실험 절차

The synthesis of this compound was done by tritylation of trimethyl-3,4,5-pyrazoletricarboxylate (1680 mg, 6.94 mmol) using a procedure similar to the one described in examples 2 and 3 for the synthesis of other tritylated pyrazole derivatives. The starting pyrazole reacted with sodium hydride (405 mg, 10.13 mmol) in dry dimethylformamide (80 mL) for 30 min at room temperature. Then, trityl chloride (1935 mg, 6.94 mmol) was added and the reaction mixture stirred overnight at room temperature. After removal of the solvent under vacuum, the resulting residue was washed with distilled water, n-hexane, and finally dried under vacuum to afford the title compound, as a white microcrystalline solid. Yield: 90% (3.034 g, 6.26 mmol).

출처