반응 #657257

반응 방정식

1-trityl-4-ethoxymethylpyrazole

→

4-ethoxymethylpyrazole

수율 44.0%

용매

ethanol acetone

HCl

반응 조건

후처리

1. 1
   workup.ADDITIONwas added to the resulting solution
2. 2
   온도After cooling to room temperature
3. 3
   여과the reaction mixture was filtered
4. 4
   세척washed with dichloromethane
5. 5
   추출extracted with dichloromethane
6. 6
   건조dried over MgSO4
7. 7
   기타the solvent was evaporated under vacuum

실험 절차

1-trityl-4-ethoxymethylpyrazole (1.800 g, 4.88 mmol) was dissolved in a mixture of ethanol/acetone (15 ml/5 ml) and 30 mL of 2N HCl was added to the resulting solution. The mixture was heated at 80° C. for 2 h. After cooling to room temperature, the reaction mixture was filtered and washed with dichloromethane. The aqueous layer was basified with 2N NaOH and extracted with dichloromethane. The organic layers were combined, dried over MgSO4 and the solvent was evaporated under vacuum yielding compound 4-ethoxymethylpyrazole as a white oil. Yield: 44% (270 mg, 2.14 mmol).

출처