반응 #657255

ord-43ed1bcb2315415481cb713c6d8ab10b

반응 방정식

OCc1cnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
1-trityl-4-hydroxymethylpyrazole
[H-].[Na+]
sodium hydride
CI
iodomethane
COCc1cnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
1-trityl-4-methoxymethylpyrazole
수율 93.0%

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타This compound is obtained

실험 절차

This compound is obtained by reacting 1-trityl-4-hydroxymethylpyrazole (555 mg; 1.63 mmol) in dry tetrahydrofuran with sodium hydride (98 mg; 2.44 mmol) and iodomethane (0.5 mL; 8.15 mmol). Yield: 93% (536 mg, 1.51 mmol).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09023315B2uspto-grants-2015_05