반응 #657252

반응 방정식

20

5-Bromo-2,3-dihydrobenzofuran-7-carbaldehyde

(1S,2S) pseudoephedrine

→

21

수율 79.0%

(4S,5S)-2-(5-bromo-2,3-dihydrobenzofuran-7-yl)-3,4-dimethyl-5-phenyl-1,3-oxazolidine

수율 79.0%

용매

benzene

반응 조건

후처리

1. 1
   기타Solvent removal
2. 2
   기타yielded yellow crystals which
3. 3
   기타were recrystallized from a minimum of hot hexanes

실험 절차

A sample of 20 (650 mg, 2.9 mmol) and (1S,2S) pseudoephedrine (500 mg, 3.0 mmol) in 40 mL of benzene was refluxed overnight using a Dean-Stark trap. Solvent removal yielded yellow crystals which were recrystallized from a minimum of hot hexanes to give white crystals of 21 (841 mg, 79%), mp=83.5-85.5° C.

출처