반응 #65693

반응 방정식

sodium

m-bromothiophenol

γ-butyrolactone

→

4-(m-bromophenylmercapto)butyric acid

용매

ethanol

반응 조건

후처리

1. 1
   온도heated to reflux
2. 2
   기타The separated carboxylic acid sodium salt was removed by filtration
3. 3
   세척washed with a small amount of ether
4. 4
   workup.DISSOLUTIONdissolved in 300 ml of water
5. 5
   온도while cooling with ice
6. 6
   추출the free carboxylic acid was extracted with ether
7. 7
   기타the ethereal solution was dried
8. 8
   기타evaporated

실험 절차

3.74 g of sodium were dissolved in 77 ml of absolute ethanol under argon. The solution was treated dropwise with 25 g of m-bromothiophenol and heated to reflux. Thereafter, 12.4 ml of γ-butyrolactone were added and the reaction mixture was heated to 110° C. for 5 hours. The separated carboxylic acid sodium salt was removed by filtration, washed with a small amount of ether and dissolved in 300 ml of water. The solution was acidified to pH 2 with 1N HCl while cooling with ice, the free carboxylic acid was extracted with ether, the ethereal solution was dried and evaporated. There were obtained 33.1 g of 4-(m-bromophenylmercapto)butyric acid.

출처