반응 #656787

반응 방정식

dichloromethyl 2-(p-chlorophenoxy)-ethyl ether

triethyl phosphite

ethyl chloride

→

Tetraethyl [2-(p-chlorophenoxy)-ethoxymethylene]-bisphosphonate

용매

ether

반응 조건

후처리

1. 1
   온도the mixture was cooled
2. 2
   세척washed with aqueous sodium bicarbonate
3. 3
   기타dried
4. 4
   기타evaporated
5. 5
   기타Unreacted triethyl phosphite was removed in vacuo
6. 6
   기타the crude product was used in the next step without further purification

실험 절차

Anhydrous zinc chloride (10 g) was added at 150° C. to a mixture of dichloromethyl 2-(p-chlorophenoxy)-ethyl ether (5.1 g) and triethyl phosphite (6.9 ml). When the evolution of ethyl chloride ceased, the mixture was cooled, taken up in ether (250 ml), washed with aqueous sodium bicarbonate, dried and evaporated. Unreacted triethyl phosphite was removed in vacuo, and the crude product was used in the next step without further purification.

출처