반응 #65614

반응 방정식

(2S,4S)-2-carbamoyl-4-(4-methoxybenzylthio)pyrrolidine hydrochloride

sodium hydroxide

→

title compound

(2S,4S)-4-(4-Methoxybenzylthio)-2-pyrrolidinecarboxylic acid

용매

hydrochloric acid

반응 조건

후처리

1. 1
   workup.STIRRINGwhilst stirring
2. 2
   기타The crystals which separated
3. 3
   여과were collected by filtration
4. 4
   세척washed with water
5. 5
   기타dried in the air

실험 절차

4.0 g of (2S,4S)-2-carbamoyl-4-(4-methoxybenzylthio)pyrrolidine hydrochloride were dissolved in 40 ml of 2N aqueous hydrochloric acid, and the resulting solution was stirred for 1.5 hours on an oil bath at 95°-100° C. At the end of this time, the solution was cooled to room temperature, and then about 40 ml of a 2N aqueous solution of sodium hydroxide were added to the solution, whilst stirring, to adjust its pH to a value of between 4 and 6. The crystals which separated were collected by filtration, washed with water and dried in the air, to yield 3.25 g of the title compound as crystals, melting at 198°-200° C.

출처