반응 #65509

반응 방정식

3-chloro-4-hydroxy-5-methoxybenzyl alcohol

methyl 2-bromophenylacetate

potassium carbonate

→

title compound

수율 64.0%

Methyl 2-(2-Chloro-4-Hydroxymethyl-6-Methoxyphenoxy)-2-Phenylacetate

수율 64.0%

용매

acetone

반응 조건

후처리

1. 1
   온도refluxed overnight
2. 2
   여과filtered
3. 3
   기타evaporated in vacuo
4. 4
   기타The residual oil was purified on a silica gel flash chromatography column
5. 5
   세척eluted with 35% ethyl acetate/hexane

실험 절차

To a solution of 0.500 g (2.65 mmol) of 3-chloro-4-hydroxy-5-methoxybenzyl alcohol (Bader) and 0.668 g (1.1 eq) of methyl 2-bromophenylacetate dissolved in 5 mL acetone was added 0.733 g (2 eq) of anhydrous potassium carbonate and the reaction mixture was stirred and refluxed overnight. The reaction mixture was cooled to room temperature, filtered and evaporated in vacuo. The residual oil was purified on a silica gel flash chromatography column eluted with 35% ethyl acetate/hexane to afford 0.570 g (64%) of the title compound.

출처