반응 #65483

반응 방정식

product

(4-bromophenyl) (2-butyl pyrazolo(1,5-a) pyridin-3-yl) methanone

dimethylformamide

→

expected product

(2-butyl pyrazolo (1,5-a)pyridin-3-yl) carbonyl benzonitrile

용매

water

반응 조건

후처리

1. 1
   온도was refluxed for 24 hours
2. 2
   여과400 ml of ethyl acetate, filtered
3. 3
   추출extracted with ethyl acetate
4. 4
   기타After drying
5. 5
   여과filtering
6. 6
   기타were eliminated under reduced pressure at a temperature of about 60° C.

실험 절차

A mixture of 1.5 g of the product of Example 1, 100 ml of dimethylformamide and 3 g of cuprous cyanide was refluxed for 24 hours and the reaction mixture was taken up in 400 ml of water and 400 ml of ethyl acetate, filtered and extracted with ethyl acetate. After drying and filtering, the solvents were eliminated under reduced pressure at a temperature of about 60° C. to obtain after chromatography on silica (essence G: 80/ethyl acetate: 20) 1.03 g of the expected product melting at 116° C.

출처