반응 #654322

반응 방정식

ethyl acetate

4-fluorobenzaldehyde

sodium hydroxide

acetone

water

→

4-(4-fluorophenyl)-3-buten-2-one

수율 82.3%

반응 조건

후처리

1. 1
   workup.ADDITIONdropwise and during the course of addition, temperature
2. 2
   기타was kept no higher than 25° C., while the mixture
3. 3
   기타the phases were separated
4. 4
   세척the organic phase was washed with water three times
5. 5
   기타dried
6. 6
   농축concentrated

실험 절차

In a 250 ml single neck flask was charged 12.4 g (100 mmoles,1.0 eq) of 4-fluorobenzaldehyde dissolved in 30 ml of acetone. To this was added 5 g of 10% aqueous sodium hydroxide solution (12.5 mmoles, 0.125 eq), dropwise and during the course of addition, temperature was kept no higher than 25° C., while the mixture was agitated continuously for 30 minutes. To the mixture was added 50 ml of water, followed by 100 ml of ethyl acetate, the phases were separated and the organic phase was washed with water three times and then dried, and concentrated to obtain 13.5 g of 4-(4-fluorophenyl)-3-buten-2-one as a faintly yellow oil in 82.3% yield.

출처