반응 #654057

반응 방정식

Sodium triacetoxyborohydride

3-oxo-3,4-dihydro-2H-benzo[1,4]-oxazine-6-carbaldehyde

4-(piperazin-1-yl)-benzenesulfonamide

→

4-[4-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-piperazin-1-yl]-benzenesulfonamide

수율 4.4%

용매

THF

반응 조건

후처리

1. 1
   기타The reaction is quenched by addition of 50 mL of water
2. 2
   기타the THF is removed under reduced pressure
3. 3
   여과The precipitate is collected by filtration
4. 4
   기타recrystallized from methanol

실험 절차

Sodium triacetoxyborohydride (1.2 g, 5.9 mmol) is added to a solution of 3-oxo-3,4-dihydro-2H-benzo[1,4]-oxazine-6-carbaldehyde (0.5 g, 2.8 mmol) and 4-(piperazin-1-yl)-benzenesulfonamide (0.17 g, 3.1 mmol) in 20 mL of THF. The mixture is stirred at room temperature overnight. The reaction is quenched by addition of 50 mL of water, and the THF is removed under reduced pressure. The precipitate is collected by filtration and recrystallized from methanol to give 0.05 g (4% yield) of 4-[4-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-piperazin-1-yl]-benzenesulfonamide; mp 150-153° C.

출처